ABSTRACT

Objective: To compare and correlate hematological parameters (complete blood picture, prothrombin time, activated partial thromboplastin time, blood group and factor VIII levels) in obligate female carriers of Hemophilia A with control women.

Study Design: A cross-sectional comparative study

Place and Duration: Department of Pathology, Army Medical College, Rawalpindi from 1^st January 2017 1^st January 2018.

Methodology: Obligate Female carriers (Group-1) of hemophilia A and control women (Group-2) from all ages were included except those not meeting inclusion criteria. Nine ml of blood was extracted after informed consent from each healthy control and female carrier, and was tested for blood complete picture, PT, APTT, Factor VIII and blood groups.

Results: A total of 66 patients were included and 33 were obligate female carriers and 33 females were included as controls. Mean age of carriers vs controls was statistically insignificant (25+13.1 vs.27+ 11.8, p =0.776). Statistically significant differences were not observed between mean hemoglobin, mean white cell count, mean platelet count and mean prothrombin time of carriers and controls. However mean activated partial thromboplastin time was significantly different between two groups (carriers vs controls, 37.09+5.13 vs 31.8+1.92, p=0.000). Factor VIII levels were lower in carriers than in non-carriers. Levels observed were statistically significant (0.000) and strongly correlated with APTT in carriers vs controls. Blood groups were also statistically significant between carriers and controls (0.004) and showed significant correlation with factor VIII levels in carriers (0.001).

Conclusion: Factor VIII levels were lower and statistically significant between carriers and controls and also showed statistically significant correlations with APTT in hemophiliac carrier females. No correlation was found with age, hemoglobin, white cell count, platelet count, blood grouping and prothrombin time.

Keywords: Hemophilia A, Carrier females, APTT, Blood grouping, Prothrombin time, Factor VIII.

How to Cite This:

Kiani SN, Basharat M. Correlation of Hematologic parameters with factor VIII levels in obligate female carriers of Hemophilia A.Isra Med J. 2020; 12(2): 60-63.

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