Isra Medical Journal

Title:

Propofol Auto-Coninduction versus Midazolam Propofol Coninduction; A Comparative Study Applying Priming Technique

Authors:

Ammar Ali Shah, Latif Abid, Ayesha Nazir, Zubair Tariq, Farah Naz

Published on:

2017-08-31

Journal Reference:

Volume 9- Issue 4 July - August 2017

Pages:

201-204

Download Abstract:

Download

DOI:

ABSTRACT

OBJECTIVE: To assess the applicability of priming technique in case of anesthetic agentspropofol and midazolam.

STUDY DESIGN: A Randomized controlled trial.

PLACE AND DURATION: Department of Anaesthesiology and Intensive Care, Holy Family Hospital, Rawalpindi from 1st of January 2016to 30th June 2016.

METHODOLOGY: Current study had ninety participants divided equally in 3 groups with equal number of patients. Group I was given0.5 mg/kg propofol intravenously which was about twenty percent of the worked out dose of propofol for anesthesia induction. GroupII was injected 0.05 mg / kg intravenous midazolam while Group III was injected 3 ml 0.9 % saline, which was succeeded two minafterwards in all the groups with intravenous propofol injection till the loss of corneal reflex. Hemodynamic variables systolic bloodpressure, diastolic blood pressure and mean arterial blood pressure were noted.

RESULTS: The results showed a statistically significant reduction in the dosage requirement of induction agents. Induction dosageworked out to be 23.65% lower in the Group I (propofol auto-coinduction group) and 12.87% lesser in the Group II (midazolam coinductiongroup) in comparison to the control. The hemodynamics remained more stable in Group II (midazolam propofolcoinductiongroup) during per intubation period.

CONCLUSIONS: The principal of co-induction was found to be efficacious in terms of anesthesia induction agentspropofol andmidazolam.

KEYWORDS: Priming principal,coinduction, auto-coinduction, propofol, midazolam.