ISRA MEDICAL JOURNAL p-ISSN: 2073-8285
e-ISSN: 2413-9289
A Biannual Published Journal of Isra University, Pakistan
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الثلاثاء 11 جمادى الثانية 1447
Tuesday 02nd December 2025
Current Issue:
Volume 16 - Issue 2 July – Dec 2024 Archives Instructions for Authors
Manuscript Submission Peer Review Process Instructions for Reviewer Ahead of Printing Article Tracking
Title:
Cyclophosphamide – Induced Oxidative Damage: Preventive Role of Zinc, Ascorbic Acid and CedrusDeodara Root Oil
Authors:
Maria Kazi, Mumtaz Ali Qureshi, Mohammad Ahmed Azmi
Published on:
2017-08-31
Journal Reference:
Volume 9- Issue 4     July - August 2017
Pages:
252-256
Download Abstract:
DOI:
ABSTRACT
OBJECTIVES: To evaluate the protective role of zinc, ascorbic acid and cedrusdeodararoot oil in cyclophosphamide- induced changesin antioxidant enzymatic activity in adult Wistar Strains albino rats.
STUDY DESIGN: An Experimental Study.
PLACE & DURATION: Department of Biochemistry Isra University, Hyderabad from 1st January 2014 to 31st December 2015.
METHODOLOGY: Total sixty albino rats of either gender were selected. The animals were divided into six groups, 10 in each group onthe basis of treatment protocol. Group- A: Control rates 0.9% saline, Group-B: Treated with single dose of cyclophosphamide1mg/100g in tra-peritoneal (i.p) on first day, Group –C: Received ascorbic acid 500mg/100g orally for 21 days in CPA-induced group,Group-D: Received zinc sulphate 0.1 mg/100g orally for 21 days in CPA-induced group, Group-E: Received Cedrusdeopararoot oil 0.05mg/100g, zinc sulphate 0.05mg/ 100g and Cedrusdeodararoot oil 0.05mg/g i.p for 21 days in CPA induced group.
RESULTS: The data showed that serum superoxide dismutase, glutathione peroxidase, reduced glutathione and catalase were foundstatistically significant P<0.000 among the control and treated group of animals. Animals of group B when compared with controlgroup A and also with other groups showed statistically significant difference in antoxidant enzymes (P<0.00001). Treated group Eshowed significant increase in antioxidant enzymes activity and improvement in cyclophosphamide induced animals.
CONCLUSION: The Cedrusdeodararoot oil exerts potent free radical scavenging property as well as potent antioxidant effect againstcyclophosphamide – induced oxidative changes.
KEYWORDS: Cyclophosphamide, Antioxidant enzymes, Zinc Sulphate, Ascorbic acid, Cedrusdeodararoot oil, Albino rats.