OBJECTIVE: To determine the Role of Iodine Complex in treatment of Cystic Ovaries due to subclinical hypothyroidism.
STUDY DESIGN: Pilot clinical study
DURATION OF STUDY: From 01-03-2012 to 30-10-2012 at Isra University Karachi Campus.
PLACE OF STUDY: Isra University, Karachi Campus.
PATIENTS AND METHODS: A total of 30 patients were included in the study. This study all of them were ensured that they were not taking any medication within the last 6 months. Investigations including complete blood picture, serum fasting insulin levels, Thyroid stimulating hormone (TSH), serum free T4 (FT4), free T3 (FT3), serum FSH, LH, Free testosterone, androstenedione and ultrasound of pelvis were carried out in all patients at the start of study and thereafter after four and eight weeks. Exclusion criteria were frank hypothyroidism, other metabolic and cardiac disease, hepatic and renal dysfunction. Capsule Idomarine (Iodine Polymer) 50mg twice daily were prescribe for 8 weeks.
RESULTS: The age of patients ranges between 18—35 years. Out of 30 patients n=10 (33.3%) were unmarried, n=7 (23.4%) were married with history of recurrent miscarriages and n=13 (43.3%) married woman with primary infertility. There was marked improvement in the symptoms with return of regular menstrual cycles in almost all patients. Two (6.6%) patients conceive within a period of 6 months’ time.
CONCLUSION: The Iodine complex marked by the name of Idomarine capsules are found to be very effective in cases of PCO due to subclinical hypothyroidism.