Title:
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Role of Topical Diltiazem and Topical Glyceryl Trinitrate in Chronic Anal Fissure
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Authors:
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Published on:
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2018-04-30
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Journal Reference:
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Volume 10 - Issue 2 Mar - Apr 2018
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Pages:
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86-90
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Download Abstract:
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DOI:
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OBJECTIVE: To compare the role of topical diltiazem and glyceryltrinitrate in terms of healing in chronic anal fissure.
STUDY DESIGN: A Randomized Control Trial
PLACE AND DURATION: Department of Surgery, Benazir Bhutto Hospital, Rawalpindi from 1st June 2012 to 30th November 2012.
METHODOLOGY: All patients with clinical diagnosis of chronic anal fissure were equally divided in two groups. One group received 0.2% glyceryltrinitrate ointment while other received 2% diltiazem paste topically. Both groups were compared in terms of healing and frequency of headache after 6 weeks of treatment.
RESULTS: Among total 140 patients, the 85.7% patients had chronic anal fissure posteriorly while rest of patients had it anteriorly.
In glyceryltrinitrate group, the healing rate after 6 weeks was 62.9% while in diltiazem group the rate was 78.6% (p value 0.041).
The frequencies of headache were 44.3% and 21.4% in glyceryltrinitrate and diltiazem groups respectively (p value 0.004).
CONCLUSION: The diltiazem is superior to the glyceryltrinitrate in terms of healing and side effects when used topically for the management of chronic anal fissure.
KEYWORDS: Fissure in Ano, Chemical Sphincterotomy, Glyceryltrinitrate Ointment, Diltiazem Paste, Healing, Headache.
HOW TO CITE THIS:
Altaf B, Shah FH, Akhtar M, Wasim S. Role of Topical Diltiazem and Topical Glyceryl Trinitrate in Chronic Anal Fissure. Isra Med J.
2018; 10(2): 86-90.
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