ISRA MEDICAL JOURNAL p-ISSN: 2073-8285
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Title:
Role of Lipid profile and Biochemical markers in Non-alcoholic Fatty Liver Disease patients in tertiary care hospital, Lahore
Authors:
Kiran Namoos, Waqas Shabbir
Published on:
2021-03-31
Journal Reference:
Volume 13 - Issue 1     Jan - Mar 2021
Pages:
43-47
Download Abstract:

  ABSTRACT

Objective: To determine biochemical markers and lipid profile in patients with and without nonalcoholic fatty liver disease, and also compare their possible association with degrees of nonalcoholic fatty liver disease.

Study Design: Descriptive, cross sectional study

Place and Duration: Department of Gastroenterology, Lahore general hospital from 15th May 2019 to 20th January 2020.

Methodology: Through sequential sampling 650 individuals were enrolled in the study who came to hospital for routine checkup. Individuals having history of acute viral or chronic hepatitis B, C or previous liver disease were excluded. Blood sample was taken for analysis of all liver enzymes (Gamma Glutamyl Transferase, Alanine Aminotransferase and Aspartate Aminotransferase, Alkaline Phosphatase) and Lipid profile.  Also, abdominal ultrasonography was performed to assess Non-alcoholic Fatty Liver Disease and its grades.

Results: Out of the total 650 participants, 55.69% were females and 44.30% were males. Mean age of individuals having nonalcoholic fatty liver disease was 47.49+7.06. Significant association was observed between fasting blood Glucose, total Cholesterol, low density Lipoprotein to high density Lipoprotein ratio, Gamma Glutamyl Transferase, Alanine Aminotransferase and Aspartate Aminotransferase with individuals having Non-alcoholic Fatty Liver Disease (p<0.001). Results showed that there was a significant relationship between liver enzymes (p < 0.001), and the severity of fatty liver.

Conclusion: Mild elevations of biochemical markers like liver enzymes and lipid profile are associated with Non-alcoholic Fatty Liver Disease.

Keywords:  Cholesterol, Fasting blood glucose, Gamma Glutamyl Transferase, Non-alcoholic Fatty Liver Disease, Obesity, Ultrasonography.

How to Cite This:

Namoos K, Shabbir W. Role of lipid profile and biochemical markers in Non-alcoholic Fatty Liver Disease patients in tertiary care hospital, Lahore. Isra Med J. 2021; 13(1): 43-47.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.