e-ISSN: 2413-9289
Excellence in Medical Education
السبت 13 ذو القعدة 1441
Saturday 04th July 2020
Current Issue:
Volume 11 - Issue 6, Nov - Dec 2019
Archives Instructions for Authors Manuscript Submission Review Process Instructions for Reviewer Ahead of Printing Article Tracking
IMJ is recognized by;

- Higher Education Commision of Pakistan (HEC)
- Pakistan Medical & Dental Council (PMDC)

IMJ is Covered by;
- Directory of Open Access scholarly Resources (ROAD)
- Index Copernicus International (IC Journals Master List)
- Index Medicus for the Eastern Mediterranean Region (IMEMR)
- PakMediNet
- BiblioMed
Effect of intraoperative low dose ketamine infusion on postoperative analgesia: A randomized controlled trial.
Muhammad Atif, Tassadaq Khurshid, Inam Ul Haque, Muhammad Javad Yousaf, Fatima Tassadaq Syed
Published on:
Journal Reference:
Volume 11 - Issue 3     May - June 2019
Download Abstract:



Objective: To evaluate the effect of subanesthetic dose of ketamine on postoperative pain scores and narcotic consumption in patients undergoing abdominal surgery under general anesthesia.

Study Design: Randomized, double blinded controlled trial.

Place and Duration: At the Department of Anesthesia, Combined Military Hospital, Khuzdar from 1st February 2018 to 31st January 2019.

Methodology: Adult patients were randomly allocated into two groups of equal size to receive either IV ketamine bolus, 0.25mg/kg followed by IV infusion, 0.15mg/kg/h (group A) or the same volume/kg of saline (group B). A visual analogue scale (VAS) was used to measure each patient's level of pain on arrival in post anesthesia care unit, at 1, 3, 6, 12, and 24 hours after surgery. Total postoperative morphine consumption and the incidence of side effects were also recorded.

Results: Intraoperative low dose ketamine resulted in effective analgesia in first 12 h postoperatively, seen by low pain scores (P=<0.05). The total morphine consumption was also reduced in the ketamine group (P=<0.05). No serious psychomimetic side effects were noted in both the groups.

Conclusion: Intraoperative low dose ketamine infusion should be considered as an adjunct to opioids for postoperative pain management.

Keywords: Abdominal surgery, Postoperative pain, Postoperative analgesia, Ketamine, Morphine, Narcotic consumption, Psychomimetic side effects.

How to Cite This:

Atif M, Khurshid T, Haque IU, Yousaf MJ, Syed FT. Effect of intraoperative low dose ketamine infusion on postoperative analgesia: A randomized controlled trial. Isra Med J. 2019; 11(3): 154-158.


This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.