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Correlation of Serum IgA anti Tissue Transglutaminase Antibody levels with Histopathological grades of Celiac disease using Corazza Grading system
Anum Usman, Noor Khan Lakhnana, Ayesha Sarwar, Mudassira Zahid
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Volume 13 - Issue 1     Jan - Mar 2021
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Objective: To correlate serum IgA anti-tissue transglutaminase antibody levels with the histopathological grades of celiac disease using Corazza grading system

Study Design: Descriptive Cross- sectional study

Place and Duration: At Al Nafees Medical College and Hospital Department of Pathology from April 6, 2015 to June 10, 2016.

Methodology: From all the enrolled patients, based upon inclusion and exclusion criteria, endoscopic biopsies were processed routinely for histopathological analysis.  Corazza Grading system was used for grading the morphological findings. Anti-Tissue transglutaminase (tTG) IgA antibodies were measured by the ELISA (Enzyme-Linked Immunosorbent Assay) method. Both biopsy data and serological marker were correlated.

Results: 77 patients were included in this study, out of which 55 were diagnosed as celiac disease patients.  Gender distribution included 38.9% males and 61.1% females. According to Corraza Grading System, there were 28.6% cases in Corraza 0 and 22% cases in Corraza A whereas Corraza B1 and B2 included 35% and 14.3% cases respectively. After correlation with anti- tTG IgA Ab titers, 27.2% patients had negative serology. Total 22% patients in Corraza A were serologically positive and had IgA tTG Ab titers between 11 to 100 units/ml whereas in Corazza B1,only 18% patients had titers greater than 100 units/ml and Corazza B2 almost all patients had  titers greater than 100 units/ml.

Conclusion: Corazza Grading System significantly correlates with anti-tissue transglutaminase IgA Antibody titers

Keywords: Endoscopic biopsy, Celiac disease, Serology, Morphology, Marsch,  Tissue transglutaminase, Corazza Grading System

How to Cite This:

Usman A, Lakhnana NK, Sarwar A, Zahid M. Correlation of Serum IgA anti Tissue Transglutaminase Antibody levels with Histopathological grades of Celiac disease using Corazza Grading system. Isra Med J. 2021; 13(1): 39-42.

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