ISRA MEDICAL JOURNAL p-ISSN: 2073-8285
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Volume 11 - Issue 5, Sep - Oct 2019
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Title:
Correlation of Cystatin C with Glomerular Filtration Rate and Urine Albumin – An early prediction of kidney status in type 2 Diabetes Mellitus
Authors:
Atteaya Zaman, Amena Rahim, Aqsa Malik
Published on:
2019-10-31
Journal Reference:
Volume 11 - Issue 5     September - October 2019
Pages:
359-362
Download Abstract:

ABSTRACT

 

Objective: To correlate Cystatin C with GFR and urinary albumin in order to find it out as a marker of early detection of kidney disease (diabetic nephropathy).
Study Design: A cross sectional analytic study
Place and Duration: The Department of Biochemistry, Islamic International Medical College from 15th March, 2016 to 14th March, 2017.
Methodology: The diabetic patients having urinary albumin creatinine level between 30 mg/g to 300 mg/g were selected. The estimation of urinary albumin levels and cystatin C levels were carried out on IMAGIN Specific Protein Analyzer. GFR was calculated using standardized clinical and pathological parameters of creatinine levels, patients age, gender and body size and a cutoff value of GRF of < 60 ml was set for probable nephropathy.
Results: Mean age of patients was 56.1 ± 5.4 years with male predominance (58.5%). Non-parametric spearman’s correlation coefficient found out that GFR was negatively correlated with Cystatin C (-.305). The correlation coefficient for and Cystatin C and urinary albumin was (0.517) showing a perfect positive linear relation.
Conclusion: Cystatin C was found significantly correlated with GFR and urinary albumin, thus, validating previous findings regarding Cystatin C’s role as an early marker of kidney diseases.
Keywords: Diabetic nephropathy, Clinical predictor, Glomerular filtration rate, Urinary albumin, Cystatin C
 
How to Cite This:


Zaman A, Rahim  A, Malik A. Correlation of cystatin c with glomerular filtration rate and urine albumin – an early prediction of kidney status in type 2 diabetes mellitus.Isra Med J. 2019; 11(5): 359-362.


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