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الأربعاء 14 شعبان 1441
Wednesday 08th April 2020
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Assessment of immunological response of Hepatitis B vaccination in patients of Chronic Hepatitis C (HCV)
Muhammad Waseem Abbas, Rukhsar Javaid, Muhammad Nouman Iqbal, Muhammad Arslan Iqbal
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Volume 11 - Issue 5     September - October 2019
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Objective: To evaluate the synthesis of anti-Hbs in response to the Hepatitis-B vaccination in patients with Hepatitis C infection in comparison with healthy people.
Study Design: Interventional Study.
Place and Duration: Department of Medicine and Department of Gastroenterology, Nishtar Hospital, Multan, from May 20, 2016 to June 15, 2018.
Methodology: A total of 83 subjects were enrolled, 41 were patients of Hepatitis C infection (HCV) and 42 were normal healthy individuals. Baseline anti-Hbs was done before vaccination. All the enrolled subjects (healthy and HCV patients) were administered Hepatitis-B vaccine intramuscularly according to recommended schedule of 0, 1 and 6 months. Anti-Hbs were measured after one month of third injection.
Results: Sero-protective representation was almost equal (more than 90%) for both groups (i.e. HCV patients and healthy individuals). Males were more sero-protected than females for both HCV patients and healthy individuals. The representation of sero-protection for males in HCV patients and healthy individuals were 56.09 % and 50.00 % respectively while the representation of sero-protection for females were 36.58 % in HCV patients and 47.61 % in healthy individuals.
Conclusion: The standard dosage of hepatitis B vaccine gave sero-protective levels in both groups i.e. normal healthy individuals and HCV patients. The antibody titers were almost equal in both groups asHCV infection has little or no effect on immune response of body.
Keywords: Hepatitis C virus, Hepatitis B vaccination, Antibody titers, HCV patients, Humoral immunity
How to Cite This:

Abbas MW, Javaid R, Iqbal MN, Iqbal MA. Assessment of immunological response of Hepatitis B vaccination in patients of Chronic Hepatitis C (HCV).Isra Med J. 2019; 11(5): 390-393.

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