ISRA MEDICAL JOURNAL p-ISSN: 2073-8285
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الأربعاء 22 ذو الحجة 1441
Wednesday 12th August 2020
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Volume 11 - Issue 6, Nov - Dec 2019
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Title:
Antioxidant effects of walnuts on malondialdehyde levels raised by lead toxicity in mice
Authors:
Roomisa Anis, Muhammad Waseem Kausar, Naveeda Zaigham, Muhammad Burhan Ul Haq, Sobia Humerah, Beenish Zafar
Published on:
2019-12-31
Journal Reference:
Volume 11 - Issue 6     November - December 2019
Pages:
444-448
Download Abstract:
 ABSTRACT
 
Objective: To evaluate the antioxidant effects of walnuts on raised levels of Malondialdehyde (MDA) by lead toxicity.
Study Design: Quasi Experimental study
Place and Duration: Department of Biochemistry, ANMCH, Islamabad, Pakistan in collaboration with National Institute of Health Islamabad. The duration of the study was six months from November, 2015 to April, 2016
Methodology: A total of 60 BALB/c mice were divided into three groups of 20 mice each. Group I was given normal standard diet. Group II was given lead acetate in drinking water with normal diet without any supplementation. Group III was given lead acetate with diet supplemented with walnuts. Levels of malondialdehyde were measured by using Thiobarbituric acid reactive substances (TBARS) method at the end of study.
Results: The data obtained from this study indicates that lead caused increase in serum Malondialdehyde (38.06±2.99.) levels in group II. Supplementation of walnut along with lead showed decrease in serum malondialdehyde levels (7.91±2.23) in group III as compared to group II.
Conclusion: Walnuts are rich in antioxidants and prevent against the lead induced oxidative stress by decreasing serum Malondialdehyde levels
Keywords: Lead Poisoning, Malondialdehyde, Walnuts

How to Cite This:


AnisR, KausarMW, ZaighamN, HaqMBU, HumerahS, Zafar B. Antioxidant effects of walnuts on malondialdehyde levels raised by lead toxicity in mice. Isra Med J. 2019; 11(6): 444-448.


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