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Excellence in Medical Education
الخميس 03 رجب 1441
Thursday 27th February 2020
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Volume 11 - Issue 4-B, July - Aug 2019
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Anti-microbial suseptability of Escherichia coli and Klebsiella spp: A review of 126 clinical isolates.
Fatima Iqbal Khan, Sheikh Abdul Khaliq, Bilqees Fatima
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Journal Reference:
Volume 11 - Issue 4-B     July - August 2019
Download Abstract:
Objective: To analyze the resistance patterns of antibiotics against infectious agents causing blood, urine and pus infections.
Study Design: Prospective experimental study.
Place and Duration: Pharmaceutical Microbiology Lab, Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi from 8th January to 21st June 2018.
Methodology: As126 Clinical isolates of E.coli and Klebsiella spp. were collected from various pathological laboratories of Karachi. Antimicrobial susceptibility testing was performed by Kirby-Bauer method for disks of four antibiotics; Imipenem, Cefotaxime, Nalidixic acid and Gentamicin. 
Results: Among 126 clinical isolates, (66%) are Escherichia coli, (34%) are Klebsiella species. (63%) isolates have been obtained from the urine culture, (33%) from blood and (4%) from pus causing urinary tract infection, bacteremia and soft tissue infection respectively. Imipenem is found to have significantly (p=0.0001) highest susceptibility against E.coli (87%) and Klebsiella specie.(91%). However, E.coli (40%) and Klebsiella specie. (93%) are highly resistant from Cefotaxime, while almost 50% organism are resistant from Gentamicin (53%) and Nalidixic acid (33%).    
Conclusion: Imipenem has been found to be the most effective of all tested antibiotics while Cefotaxime has developed resistance from these microorganisms. 
Keywords: Antimicrobial susceptibility, Escherichia coli, Klebsiella, Disk diffusion method, Resistance, Antibiotics

How to Cite This:

Khan FI, Khaliq SA, Fatima B. Anti-microbial suseptability of Escherichia coli and Klebsiella spp: A review of 126 clinical isolates.Isra Med J. 2019; 11(4)-Part B: 271-274.

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