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A comparative study of Gabapentin and intravenous Lidocaine for post-operative pain control after total knee replacement
Jamal Hafeez,Shahbaz Ahmad, Asif Mahmood, Liaqat Ali, Muhammad Yousuf Bandesha
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Volume 13 - Issue 2     Apr - Jun 2021
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Objective: To assess the side effects, efficiency, and outcomes of Gabapentin, Intravenous Lidocaine, and their combination for the reduction of postoperative pain after the total knee replacement.

Study Design: A Case-Control study was done.

Place and Duration: At Trauma and Orthopedic Department, Mukhtar A Sheikh Hospital Multan, from March 03,2020 to August 03, 2020

Methodology: Sixty-six patients were included in the study who were placed in three study groups. Group A, B, and C were given recommended doses of intravenous lidocaine, Gabapentin orally, and their combination, respectively, a standard time before the start of operation. The administration of drugs was followed by giving anesthesia to the patients. The post-operative pain was measured through the visual analog score. According to which pain intensity was scored from 0 to 10 as per the information provided by the patients.

Results: Age, weight, gender, and duration of surgery were some factors that did not differ significantly in all groups. Pain relief was observed in all three groups within 24 hours with the mean VAS Rest Pan Score 50.0+-20.8, 40.7+-33.2 and 28.4+-19.3 in Group A, B, and C respectively which get reduced significantly to 17.5+-22.0, 16.4+-15.0 and 16.2+-18.0 in Group A, B, and C respectively till 48th hour. Nausea, vomiting, dizziness, headache and dry mouth was found as a complication of treatment in all treated groups. Nausea occurring is 22.7%, 9%, and 9%, Vomiting in 18.1%, 18.1%, and 4.5%, Dizziness in 18%, 27% and 31%, Headache in 18.1%, 13.6% and 18.1%, while Dry mouth in 18.1%, 27.2% and 27.2% in Group A, B and C respectively. 

Conclusion: To reduce the postoperative pain by analgesic effect, intravenous lidocaine as well as Gabapentin, both are effective, safe, and significant but have some side effects too. Also, their combination reduces the pain, but the side effects are decreased by its use. For overcoming postoperative nausea and vomiting, Gabapentin is the most suitable drug.

Keywords: Anaesthesia, Gabapentin, intravenous lidocaine, postoperative pain, surgery, Total knee replacement

How to Cite This:

Hafeez J, Ahmad S, Mahmood A, Bandesha MY. A comparative study of Gabapentin and intravenous Lidocaine for post-operative pain control after total knee replacement. Isra Med J. 2021; 13(2): 87-91.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.