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A Quarterly Published Journal of Isra University, Pakistan
الأحد 16 محرم 1444
Sunday 14th August 2022
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Role of Magnetic Resonance Spectroscopy in Differentiating Benign From Malignant Nodules of Thyroid Gland, Using Tissue Diagnosis as Gold Standard
Mahwish Zahra, Umaima Majeed, Muhammad Amin, Zia-ul-Islam, Atqa Firdous, Aeeza Malik
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Volume 14 - Issue 1     Jan - Mar 2022
Download Abstract:


Objective: To analyze the diagnostic accuracy role of Magnetic Resonance Spectroscopy in differentiating benign from malignant nodules of thyroid gland by using tissue diagnosis as a gold standard.

Study Design: Co-relational Analytical study.

Place and Duration: At Department of Radiology, Children Hospital and Institute of Child Health, Multan from 1st October 2017 to 1st October 2018.

Methodology: A total of seventy patients (of both genders) were recruited for this study who clinically presented with palpable thyroid nodule. The patients who had any previous surgery of thyroid, thyroid malignancy (proven by biopsy), claustrophobic and with contraindications to Magnetic Resonance Spectroscopy that is cardiovascular implanted electronic devices were excluded. Magnetic Resonance Spectroscopy was done for Choline Peak and Choline/Creatine ratio to assess thyroid nodule and results were then compared with tissue diagnosis.

Results: among total of 70 patients, malignant thyroid nodules diagnosed in 51 (72.85%) and Magnetic Resonance Spectroscopy shows true positive in 96.07% (n=49) patients and with and among them 93.87% (n=46) were found to be true positive while 6.13% were false positive. Among 24 Magnetic Resonance Spectroscopy negative patients, 16 were true negative while 05 were false negative patients (p=0.0001). Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of Magnetic Resonance Spectroscopy in diagnosing malignant thyroid nodule taking tissue diagnosis as gold standard was 93.51%, 84.35%, 95.24%, 79.51% 91.40% respectively.   

Conclusion: Magnetic Resonance Spectroscopy is an extremely sensitive and noninvasive tool which gives accurate method for diagnosing malignant thyroid nodules.

Keywords: Magnetic Resonance Spectroscopy, Thyroid Nodules, Benign, Malignant, Tissue, Diagnosis, Sensitivity

How to Cite This:

Zahra M, Majeed U, Amin M, Islam ZU, Firdous A, Malik A. Role of Magnetic Resonance Spectroscopy in Differentiating Benign From Malignant Nodules of Thyroid Gland, Using Tissue Diagnosis as Gold Standard. Isra Med J. 2022; 14(1):17-20. DOI:

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